全文获取类型
收费全文 | 18684篇 |
免费 | 1240篇 |
国内免费 | 123篇 |
专业分类
耳鼻咽喉 | 193篇 |
儿科学 | 283篇 |
妇产科学 | 265篇 |
基础医学 | 2518篇 |
口腔科学 | 437篇 |
临床医学 | 1718篇 |
内科学 | 3737篇 |
皮肤病学 | 506篇 |
神经病学 | 2188篇 |
特种医学 | 1213篇 |
外国民族医学 | 1篇 |
外科学 | 3560篇 |
综合类 | 112篇 |
一般理论 | 5篇 |
预防医学 | 611篇 |
眼科学 | 204篇 |
药学 | 1187篇 |
中国医学 | 13篇 |
肿瘤学 | 1296篇 |
出版年
2023年 | 155篇 |
2022年 | 113篇 |
2021年 | 440篇 |
2020年 | 345篇 |
2019年 | 457篇 |
2018年 | 519篇 |
2017年 | 429篇 |
2016年 | 519篇 |
2015年 | 645篇 |
2014年 | 789篇 |
2013年 | 882篇 |
2012年 | 1496篇 |
2011年 | 1598篇 |
2010年 | 977篇 |
2009年 | 900篇 |
2008年 | 1339篇 |
2007年 | 1362篇 |
2006年 | 1274篇 |
2005年 | 1195篇 |
2004年 | 1085篇 |
2003年 | 989篇 |
2002年 | 924篇 |
2001年 | 204篇 |
2000年 | 142篇 |
1999年 | 175篇 |
1998年 | 125篇 |
1997年 | 158篇 |
1996年 | 65篇 |
1995年 | 91篇 |
1994年 | 72篇 |
1993年 | 54篇 |
1992年 | 65篇 |
1991年 | 50篇 |
1990年 | 49篇 |
1989年 | 43篇 |
1988年 | 39篇 |
1987年 | 34篇 |
1986年 | 34篇 |
1985年 | 23篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 10篇 |
1980年 | 10篇 |
1979年 | 9篇 |
1978年 | 11篇 |
1975年 | 12篇 |
1974年 | 10篇 |
1973年 | 9篇 |
1972年 | 7篇 |
1970年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Fuhrer Hannah Schönenberger Silvia Niesen Wolf-Dirk Seide Svenja Meyne Johannes Gerner Stefan T. Vollmuth Christoph Beck Christopher Meckel Stephan Schocke Michael Wodarg Fritz Huttner Hagen B. Möhlenbruch Markus A. Kieser Meinhard Ringleb Peter Neugebauer Hermann 《Journal of neurology》2020,267(8):2481-2481
Journal of Neurology - The original keywords were not sufficiently precise in describing the article content. Therefore, the key words were amended to include hemicraniectomy and malignant edema. 相似文献
52.
Claudia Emanuele Carvalho-Sousa Eliana P. Pereira Gabriela S. Kinker Mariana Veras Zulma S. Ferreira Fernanda P. Barbosa-Nunes Joilson O. Martins Paulo H.N. Saldiva Russel J. Reiter Pedro A. Fernandes Sanseray da Silveira Cruz-Machado Regina P. Markus 《Journal of pineal research》2020,68(3):e12636
Environmental pollution in the form of particulate matter <2.5 μm (PM2.5) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pineal synthesis and increasing the extrapineal synthesis of melatonin. Herein, we report that the exposure of rats to polluted air for 6 hours reduced nocturnal plasma melatonin levels and increased lung melatonin levels. Melatonin synthesis in the lung reduced lipid peroxidation and increased PM2.5 engulfment and cell viability by activating high-affinity melatonin receptors. Diesel exhaust particles (DEPs) promoted the synthesis of melatonin in a cultured cell line (RAW 264.7 cells) and rat alveolar macrophages via the expression of the gene encoding for AANAT through a mechanism dependent on activation of the NFκB pathway. Expression of the genes encoding AANAT, MT1, and MT2 was negatively correlated with cellular necroptosis, as disclosed by analysis of Gene Expression Omnibus (GEO) microarray data from the human alveolar macrophages of nonsmoking subjects. The enrichment score for antioxidant genes obtained from lung gene expression data (GTEx) was significantly correlated with the levels of AANAT and MT1 but not the MT2 melatonin receptor. Collectively, these data provide a systemic and mechanistic rationale for coordination of the pineal and extrapineal synthesis of melatonin by a standard damage-associated stimulus, which activates the immune-pineal axis and provides a new framework for understanding the effects of air pollution on lung diseases. 相似文献
53.
Rachel K. Spooner Alex I. Wiesman Amy L. Proskovec Elizabeth Heinrichs‐Graham Tony W. Wilson 《Human brain mapping》2020,41(2):520-529
The ability to execute a motor plan involves spatiotemporally precise oscillatory activity in primary motor (M1) regions, in concert with recruitment of “higher order” attentional mechanisms for orienting toward current task goals. While current evidence implicates gamma oscillatory activity in M1 as central to the execution of a movement, far less is known about top‐down attentional modulation of this response. Herein, we utilized magnetoencephalography (MEG) during a Posner attention‐reorienting task to investigate top‐down modulation of M1 gamma responses by frontal attention networks in 63 healthy adult participants. MEG data were evaluated in the time–frequency domain and significant oscillatory responses were imaged using a beamformer. Robust increases in theta activity were found in bilateral inferior frontal gyri (IFG), with significantly stronger responses evident in trials that required attentional reorienting relative to those that did not. Additionally, strong gamma oscillations (60–80 Hz) were detected in M1 during movement execution, with similar responses elicited irrespective of attentional reorienting. Whole‐brain voxel‐wise correlations between validity difference scores (i.e., attention reorienting trials—nonreorienting trials) in frontal theta activity and movement‐locked gamma oscillations revealed a robust relationship in the contralateral sensorimotor cortex, supplementary motor area, and right cerebellum, suggesting modulation of these sensorimotor network gamma responses by attentional reorienting. Importantly, the validity difference effect in this distributed motor network was predictive of overall motor function measured outside the scanner and further, based on a mediation analysis this relationship was fully mediated by the reallocation response in the right IFG. These data are the first to characterize the top‐down modulation of movement‐related gamma responses during attentional reorienting and movement execution. 相似文献
54.
Die Anaesthesiologie - Im Jahr 1989 haben die Vereinten Nationen die „United Nations Convention on the Rights of the Child“ (UNCRC) beschlossen und u. a. für Kinder der... 相似文献
55.
56.
Martin Liebl Federico Pedersoli Markus Zimmermann Maximilian Schulze-Hagen Daniel Truhn Paul Sieben Saskia von Stillfried Anna Tschinaev Alexander Heinzel Christiane K. Kuhl Philipp Bruners Peter Isfort 《Journal of vascular and interventional radiology : JVIR》2021,32(6):836-842.e2
PurposeTo compare hepatic hypertrophy in the contralateral lobe achieved by unilobar transarterial radioembolization (TARE) versus portal vein embolization (PVE) in a swine model.MethodsAfter an escalation study to determine the optimum dose to achieve hypertrophy after unilobar TARE in 4 animals, 16 pigs were treated by TARE (yttrium-90 resin microspheres) or PVE (lipiodol/n-butyl cyanoacrylate). Liver volume was calculated based on CT before treatment and during 6 months of follow-up. Independent t-test (P < .05) was used to compare hypertrophy. The relationship between hypertrophy after TARE and absorbed dose was calculated using the Pearson correlation.ResultsAt 2 and 4 weeks after treatment, a significantly higher degree of future liver remnant hypertrophy was observed in the PVE group versus the TARE group, with a median volume gain of 31% (interquartile range [IQR]: 16%–66%) for PVE versus 23% (IQR: 6%–36%) for TARE after 2 weeks and 51% (IQR: 47%–69%) for PVE versus 29% (IQR: 20%–50%) for TARE after 4 weeks. After 3 and 6 months, hypertrophy converged without a statistically significant difference, with a volume gain of 103% (IQR: 86%–119%) for PVE versus 82% (IQR: 70%–96%) for TARE after 3 months and 115% (IQR: 70%–46%) for PVE versus 86% (IQR: 58%–111%) for TARE after 6 months. A strong correlation was observed between radiation dose (median 162 Gy, IQR: 139–175) and hypertrophy.ConclusionsPVE resulted in rapid hypertrophy within 1 month of the procedure, followed by a plateau, whereas TARE resulted in comparable hypertrophy by 3–6 months. TARE-induced hypertrophy correlated with radiation absorbed dose. 相似文献
57.
58.
Siegler Benedikt Hermann Oehler Beatrice Kranke Peter Weigand Markus Alexander 《Der Anaesthesist》2022,71(8):646-660
Die Anaesthesiologie - Der Postpunktionskopfschmerz („postdural puncture headache“, PDPH) zählt zu den wesentlichen Komplikationen der peripartalen neuroaxialen Analgesie. Als... 相似文献
59.
60.